He, Xiao-Yang; Zou, Peng; Qiu, Jiayin; Hou, Ling; Jiang, Shibo; Liu, Shuwen; Xie, Lan published the artcile< Design, synthesis and biological evaluation of 3-substituted 2,5-dimethyl-N-(3-(1H-tetrazol-5-yl)phenyl)pyrroles as novel potential HIV-1 gp41 inhibitors>, Product Details of C10H9NOS2, the main research area is gp41 inhibitor HIV 1 antiviral tetrazolylphenylpyrrole preparation; pyrrole tetrazolylphenyl preparation gp41 inhibitor HIV 1 antiviral.
Based on the structure of HIV-1 gp41 binding site for small-mol. inhibitors, optimization of a lead compound resulted in the discovery of a new series of 2,5-dimethyl-3-(5-(N-phenylrhodaninyl)methylene)-N-(3-(1H-tetrazol-5-yl)phenyl)pyrrole compounds with improved anti-HIV-1 activity. The two most active compounds exhibited significant potency against gp41 6-HB formation with IC50 values of 4.4 and 4.6 μM and against HIV-1 replication in the MT-2 cells with EC50 values of 3.2 and 2.2 μM, resp., thus providing a new starting point to develop highly potent small-mol. HIV fusion inhibitors targeting gp41.
Bioorganic & Medicinal Chemistry published new progress about AIDS (disease). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Product Details of C10H9NOS2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica