With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169260-97-3,5-(Trifluoromethyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.
General procedure: The carboxylic acid in question (0.55 mmol), the amine in question (0.50 mmol),1 -hydroxy-7-azabenzotriazole (HOAt, 0.75 mmol) and 1 -ethyl-3-(3-di methylaminopropyl)carbodiimide (EDO, 0.55 mmol) were dissolved in 6 mL of DMF. The resulting slurry was stirred for 24h at ambient temperature. Thereafter 3 mL of methanol and 0.2 g of silica gel 018 were added sequentially and the mixture was stirred for 2 h, thenfiltered and solid residue dissolved in 0.5-1 mL of DMSO for HPLC purification (H20:MeOH), gradient). Yield: 20- 80%., 169260-97-3
169260-97-3 5-(Trifluoromethyl)thiazol-2-amine 15388849, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; EUROPEAN MOLECULAR BIOLOGY LABORATORY; WILL, David William; REID, George; CHARAPITSA, Iryna; LEWIS, Joe; (118 pag.)WO2018/229195; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica