Bedford, Simon T.; Benwell, Karen R.; Brooks, Teresa; Chen, Ijen; Comer, Mike; Dugdale, Sarah; Haymes, Tim; Jordan, Allan M.; Kennett, Guy A.; Knight, Anthony R.; Klenke, Burkhard; LeStrat, Loic; Merrett, Angela; Misra, Anil; Lightowler, Sean; Padfield, Anthony; Poullennec, Karine; Reece, Mark; Simmonite, Heather; Wong, Melanie; Yule, Ian A. published the artcile< Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor>, Electric Literature of 1003-32-3, the main research area is thienopyrimidine aroyl carbamoyl alkylamino preparation antagonist human adenosine receptor.
The discovery of a novel class of antagonists of the human adenosine A2B receptor, thieno[3,2-d]pyrimidines I (R1 = Ph, 4-MeOC6H4, 2-thienyl, 5-methyl-2-thienyl, 2-thiazolyl, 4-pyridyl, MeNH, 1-pyrrolidinyl, etc.; R2 = H, Et, PhCH2, 3-pyridylmethyl, 3-pyridylcarbonyl, etc.; R3 = H, Cl, H2N, MeNH, EtNH, Me2N) is reported. This low mol. weight scaffold has been optimized to offer derivatives with potential utility for the alleviation of conditions associated with this receptor subtype, such as nociception, diabetes, asthma and COPD. Furthermore, preliminary pharmacokinetic anal. has revealed compounds with profiles suitable for either inhaled or systemic routes of administration.
Bioorganic & Medicinal Chemistry Letters published new progress about Adenosine A2B receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Electric Literature of 1003-32-3.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica