Doughty, Michael B.; Risinger, G. E. published the artcile< The chemistry of thiamin: studies on the dimerization of thiazolium salts>, Quality Control of 20582-55-2, the main research area is dimerization thiazolium salt; thiamin dimer.
Dimerization chem. of thiazolium salts is reported. Thiazolium salts with electron-withdrawing substituents, such as 3,4-dimethyl-5-ethoxycarbonylthiazolium iodide, yield acid- and oxygen-sensitive ethylenic dimers under conditions originally used to detect the dimerization of 3-methylbenzothiazolium iodide. The 5-ethoxycarbonyl-4-methyl-3-phenylmethylthiazolium and 5-(2-O-triphenylmethylhydroxyethyl)-4-methyl-3-phenylmethylthiazolium bromides yield stale rearranged dimers, rather than the labile ethylenic dimers, under identical conditions. 4-Methyl-5-(2-hydroxyethyl)-3-phenylmethylthiazolium bromide and thiamin hydrochloride yield rearranged dimers which were isolated as their N,O-ketal derivatives when these salts were heated in aprotic solution in the presence of DBN and K2CO3, resp. Rearranged dimers of these thiazolium salts are produced via a mechanism involving 1,3-sigmatropic rearrangement of intermediate ethylenic dimers. This dimerization chem. demonstrates the nucleophilic carbene nature of C-2 deprotonated thiazolium salts in aprotic basic solution
Bioorganic Chemistry published new progress about Dimerization. 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Quality Control of 20582-55-2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica