Majstrowicz, Katarzyna; Honnert, Ulrike; Nikolaus, Petra; Schwarz, Vera; Oeding, Stefanie J.; Hemkemeyer, Sandra A.; Baehler, Martin published the artcile< Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19>, Application of C22H23F2N3O2S, the main research area is actin motor myosin mitochondrial cellular dynamic coordination; Cell adhesion; Mitochondria; Mitosis; Myosin.
Myosin XIX (Myo19) is an actin-based motor that competes with adaptors of microtubule-based motors for binding to the outer mitochondrial transmembrane proteins Miro1 and Miro2 (collectively Miro, also known as RhoT1 and RhoT2, resp.). Here, we investigate which mitochondrial and cellular processes depend on the coordination of Myo19 and microtubule-based motor activities. To this end, we created Myo19-deficient HEK293T cells. Mitochondria in these cells were not properly fragmented at mitosis and were partitioned asym. to daughter cells. Respiratory functions of mitochondria were impaired and ROS generation was enhanced. On a cellular level, cell proliferation, cytokinesis and cell-matrix adhesion were neg. affected. On a mol. level, Myo19 regulates focal adhesions in interphase, and mitochondrial fusion and mitochondrially associated levels of fission protein Drp1 and adaptor proteins dynactin and TRAK1 at prometaphase. These alterations were due to a disturbed coordination of Myo19 and microtubulebased motor activities by Miro.
Journal of Cell Science published new progress about Bacteriophage Miro1. 2222768-84-3 belongs to class thiazole, and the molecular formula is C22H23F2N3O2S, Application of C22H23F2N3O2S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica