Nagaladinne, Nizamuddin; Abdul Ahad, Hindustan; Nayakanti, Devanna published the artcile< Design, synthesis and molecular modelling studies of 1-methyl-3-(4-substituted phenyl-1,3- thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazolin-4(1H)-ones as potent anticancer agents>, Product Details of C9H7N3O2S, the main research area is methyl phenyl thiazolyl pyridinyl dihydroquinazolinone preparation antitumor SAR ADMET; mol modeling methyl phenyl thiazolyl pyridinyl dihydroquinazolinone preparation.
The present study involved the design, synthesis, characterization and mol. docking studies of biol. active 1-methyl-3-(4-substituted phenyl-1,3-thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazoline-4-(1H)-ones I [R = 2-OH, 3-NH2, 4-Cl, etc.] which were synthesized by condensation of 2-amino-4-substituted phenylthiazoles with N-methylbenzoxazin-4-one. The N-methylbenzoxazin-4-one and 2-amino-4-substituted phenylthiazoles were synthesized from N-methylanthranilic acid with pyridine3-carboxylic acid and substituted aldehydes with thiourea, resp. The ADME properties determined the synthetic accessibility of compounds I by in silico Swiss ADME. The colorectal anticancer screening of compounds I was done by using cell HT-29 human colorectal adenocarcinoma based on mol. docking studies on 3GC7-the structure of p38alpha in complex with dihydroquinazolinone. Finally, compounds I [R = 4-Me, 3-NH2, 2,4-(OH)2, 2,4-(Cl)2] exhibited better activity at a concentration < 10μg/mL when compared to 5-fluorouracil. The ADME properties revealed that all the compounds I were within the range and docking studies showed the highest binding with glide score -7.19 and -7.027 Kcal/mol compared to the target protein -10.67 Kcal/mol. Asian Journal of Chemistry published new progress about Antitumor agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Product Details of C9H7N3O2S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica