Sunnapu, Ranganayakulu; Banoth, Saikumar Naik; Reyno, R. S.; Thomas, Aleena; Venugopal, Navyasree; Rajendar, Goreti published the artcile< Stereoselective Total Synthesis of (-)-(2S,4R)-3'-Methoxyl Citreochlorol: Preparation and Use of New Proline-Based Auxiliary for Asymmetric Acetate Aldol Reaction>, Synthetic Route of 171877-39-7, the main research area is methoxyl citreochlorol stereoselective total synthesis asym aldol.
The first stereoselective total synthesis of (-)-(2S,4R)-3′-methoxy citreochlorol and (+)-(2S,4S)-3′-methoxy citreochlorol, I (R = OH, R1 = H; R = H, R1 = OH, resp.) is demonstrated. A proline-based imidazolidinone, II, was synthesized and used as chiral auxiliary for the asym. acetate aldol reaction to generate initial chirality in the targeted mol. The geminal dichloromethane functionality was introduced by the addition of in situ-generated dichloromethyllithium to Weinreb’s amide functional group.
Journal of Organic Chemistry published new progress about Aldol addition, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Synthetic Route of 171877-39-7.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica