Lakhan, Ram; Singh, Om Prakash published the artcile< Local anesthetics. Part-III: synthesis of 2-(N-substituted or N,N-disubstituted aminoacetamido)-4 arylthiazoles>, COA of Formula: C9H7N3O2S, the main research area is aminoacetamidothiazole aryl local anesthetic preparation; phenylthiazole aminoacetamido local anesthetic preparation.
Title compounds I [R = 4-O2NC6H4, 3-O2NC6H4, 2,5-(MeO)2C6H3; R1 = Et, Me2CH, Me2CHCH2, MeEtCH; R2 = H, Et; R1R2 = piperidino] were prepared E.g., cyclocondensation of 4-O2NC6H4COMe with thiourea gave thiazole II, chloroacetylation of which followed by amination with EtNH2 gave I (R = 4-O2NC6H4, R1 = Et, R2 = H). I HCl (R = 3-O2NC6H4, R1 = MeEtCH, R2 = H) showed local anesthetic activity superior to that of procaine HCl.
Journal of the Indian Chemical Society published new progress about Local anesthetics. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, COA of Formula: C9H7N3O2S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica