Abe, Hideki; Hikichi, Takuma; Emori, Kosuke; Yokosuka, Akihito; Mimaki, Yoshihiro; Kobayashi, Toyoharu; Ito, Hisanaka published the artcile< Total Synthesis of Catunaregin and Preliminary Evaluation of Its Antitumor Activity>, Reference of 171877-39-7, the main research area is catunaregin synthesis antitumor.
The total synthesis of catunaregin in both racemic and optically active forms was accomplished. The enantioselective synthesis uses the Evans aldol strategy, with an oxazolidinone or thiazolidinethione as the chiral auxiliary. The key features include a syn-selective aldol reaction to form the Evans-syn or non-Evans-syn product, and a successive ketalization reaction of a furanyl diol derivative under acidic conditions. The biol. properties of the synthetic racemate and both enantiomers were evaluated against A549 and HL-60 human cancer cells.
European Journal of Organic Chemistry published new progress about Aldol addition, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Reference of 171877-39-7.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica