Kadam, Shuddhodan N.; Ambhore, Ajay N.; Hebade, Madhav J.; Kamble, Rahul D.; Hese, Shrikant V.; Gaikwad, Milind V.; Gavhane, Priya D.; Dawane, Bhaskar S. published the artcile< Metal-Free One-Pot Chemoselective Thiocyanation of Imidazothiazoles and 2-Aminothiazoles with in situ Generated N-Thiocyanatosuccinimide>, Formula: C9H7N3O2S, the main research area is thiocyanoimidazothiazole thiocyanoaminothiazole preparation green chem; imidazothiazole aminothiazole metal free chemoselective thiocyanation.
A chemoselective thiocyanation of imidazothiazoles and 2-aminothiazoles with use of in situ generated N-thiocyanatosuccinimide (NTS) at room temperature is described. The protocol offers mild reaction conditions and high chemoselectivity for electrophilic substitution in imidazothiazoles over nucleophilic substitution. This method provides metal-free and easy conversion of imidazothiazoles and 2-aminothiazoles into their corresponding C-3 and C-5 thiocyanates, resp., in good to excellent yield. The present protocol also offers the effective thiocyanation of bifunctional imidazothiazoles containing aliphatic -OH and C(sp2)-H bond functionalities.
Synlett published new progress about Chemoselectivity. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Formula: C9H7N3O2S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica