Fray, M. Jonathan; Bish, Gerwyn; Fish, Paul V.; Stobie, Alan; Wakenhut, Florian; Whitlock, Gavin A. published the artcile< Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors>, Safety of Thiazole-5-carboxyaldehyde, the main research area is structure piperazine derivative dual serotonin noradrenaline reuptake inhibitor.
We report the structure-activity relationships of further analogs in a series of piperazine derivatives as dual inhibitors of serotonin and noradrenaline reuptake, i.e., with addnl. substitution of the Ph rings, or their replacement by heterocycles. The enantiomers of compounds 1 and 2 were also profiled, and possessed drug-like physicochem. properties. In particular, compound (-)-2 lacked potent inhibitory activity against any of the important cytochromes P450 and high selectivity over a wide range of receptors, which is unusual for a compound that inhibits human amine transporters.
Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT reuptake inhibitors. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Safety of Thiazole-5-carboxyaldehyde.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica