Felts, Andrew S.; Rodriguez, Alice L.; Morrison, Ryan D.; Venable, Daryl F.; Manka, Jason T.; Bates, Brittney S.; Blobaum, Anna L.; Byers, Frank W.; Daniels, J. Scott; Niswender, Colleen M.; Jones, Carrie K.; Conn, P. Jeffrey; Lindsley, Craig W.; Emmitte, Kyle A. published the artcile< Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety>, HPLC of Formula: 324579-90-0, the main research area is anxiolytic mGlu5 modulator VU0409106 analog preparation anxiety; Allosteric modulator; Anxiety; CNS; Glutamate; mGlu(5).
Development of SAR in an aryl ether series of mGlu5 NAMs leading to the identification of tool compound VU0409106 is described in this Letter. VU0409106 is a potent and selective neg. allosteric modulator of mGlu5 that binds at the known allosteric binding site and demonstrates good CNS exposure following i.p. dosing in mice. VU0409106 also proved efficacious in a mouse marble burying model of anxiety, an assay known to be sensitive to mGlu5 antagonists as well as clin. efficacious anxiolytics.
Bioorganic & Medicinal Chemistry Letters published new progress about Anxiolytics. 324579-90-0 belongs to class thiazole, and the molecular formula is C6H8N2S, HPLC of Formula: 324579-90-0.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica