Funes-Maldonado, Matias; Sieng, Bora; Amedjkouh, Mohamed published the artcile< Enabling Asymmetric Alkynylation of Azaaryl Aldehydes with Soai Autocatalyst>, Electric Literature of 1003-32-3, the main research area is propargylic alc enantioselective preparation; azaaryl aldehyde dimethylzinc Soai pyrimidylalkanol chiral autocatalyst asym alkynylation.
Synthesis of enantioenriched propargylic alcs. I [R1 = Ph, Si(CH3)3; R2 = 3-pyridyl, thiazol-5-yl, 3-quinolyl, etc.] via enantioselective addition of alkynylzinc reagents to azaaryl aldehydes using Soai (R)-(5-pyrimidyl)alkanol as a chiral catalyst was reported. The autocatalyst can be generated from almost racemic environment to up to 99.5% ee and subsequently propagates this chirality to provide propargylic alcs. in up to 86% ee.
European Journal of Organic Chemistry published new progress about Alcohols, propargyl Role: SPN (Synthetic Preparation), PREP (Preparation). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Electric Literature of 1003-32-3.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica