With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
EXAMPLE 20Ethyl 2-[(3aS,6i?,7i?37ai?>6-{(li2)-l-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-7-(4-fluoro-2- methylphenvDhexahydropyrano f 3 ,4-cl pyrrol-2(3H)-yl] – 1 ,3 -thiazol e-5 -carboxylateA solution of (3aS,6i?57i?,7alambda)-6-{(li?)-l-[3,5- bis(trifluoromethyl)phenyl]ethoxy}-7-(4-fluoro-2-methylphenyI)octahydropyrano[3,4-c]pyrrole (PREP 7) (85.6 mg, 0.17mmol), N,N-diisopropylethylamine (0.035 mL, 0.20 mmol) and ethyl 2- brorno-l,3-thiazole-5-carboxylate (0.052 mL, 0.35 mmol) in 3 mL of 1 ,4-dioxane was heated at 106 0C for 18 h. Volatiles were removed and the crude was purified by reverse phase etaPLC to afford the title compound. MS: (MH)+ 647.
41731-83-3, 41731-83-3 Ethyl 2-bromothiazole-5-carboxylate 3614103, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK & CO., INC.; WO2007/75528; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica