In 2013,Savanor, Prasanna M.; Jathi, Keshavayya; Bhat, Subramanya K.; Tantry, Rajesh N. published 《Synthesis, characterization and solvatochromic studies of 3-{2-(5-bromothiazol-2-yl)diazenyl}-4-bromopyridine-2,6-diamine》.Research Journal of Chemical Sciences published the findings.Formula: C3H3BrN2S The information in the text is summarized as follows:
The 3-{2-(5-bromothiazol-2-yl)diazenyl}-4-bromopyridine-2,6-diamine was synthesized by carrying the diazotization of 5-bromothiazol-2-amine in coupling with 4-bromopyridine-2,6-diamine as a coupling component to yield a azo dye. The structure of the dye was confirmed by UV-visible spectrophotometry, FTIR, LC-MS, 1H and 13C NMR spectroscopic methods. The change in the absorption maxima of the synthesized compound in different solvents were determined, the solvatochromic property of the dye showed a medium red shift in different solvents and showed the moderate solvent dependency over the bathochromic shift. The experimental part of the paper was very detailed, including the reaction process of 5-Bromothiazol-2-amine(cas: 3034-22-8Formula: C3H3BrN2S)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Formula: C3H3BrN2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica