In 2015,Angewandte Chemie, International Edition included an article by Adams, Luke A.; Sharma, Pooja; Mohanty, Biswaranjan; Ilyichova, Olga V.; Mulcair, Mark D.; Williams, Martin L.; Gleeson, Ellen C.; Totsika, Makrina; Doak, Bradley C.; Caria, Sofia; Rimmer, Kieran; Horne, James; Shouldice, Stephen R.; Vazirani, Mansha; Headey, Stephen J.; Plumb, Brent R.; Martin, Jennifer L.; Heras, Begona; Simpson, Jamie S.; Scanlon, Martin J.. Related Products of 144060-98-0. The article was titled 《Application of Fragment-Based Screening to the Design of Inhibitors of Escherichia coli DsbA》. The information in the text is summarized as follows:
The thiol-disulfide oxidoreductase enzyme DsbA catalyzes the formation of disulfide bonds in the periplasm of Gram-neg. bacteria. DsbA substrates include proteins involved in bacterial virulence. In the absence of DsbA, many of these proteins do not fold correctly, which renders the bacteria avirulent. Thus DsbA is a critical mediator of virulence and inhibitors may act as antivirulence agents. Biophys. screening has been employed to identify fragments that bind to DsbA from Escherichia coli. Elaboration of one of these fragments produced compounds that inhibit DsbA activity in vitro. In cell-based assays, the compounds inhibit bacterial motility, but have no effect on growth in liquid culture, which is consistent with selective inhibition of DsbA. Crystal structures of inhibitors bound to DsbA indicate that they bind adjacent to the active site. Together, the data suggest that DsbA may be amenable to the development of novel antibacterial compounds that act by inhibiting bacterial virulence.4-Methyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(cas: 144060-98-0Related Products of 144060-98-0) was used in this study.
4-Methyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(cas: 144060-98-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Related Products of 144060-98-0
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica