In 2011,Hebeisen, Paul; Haap, Wolfgang; Kuhn, Bernd; Mohr, Peter; Wessel, Hans Peter; Zutter, Ulrich; Kirchner, Stephan; Ruf, Armin; Benz, Joerg; Joseph, Catherine; Alvarez-Sanchez, Ruben; Gubler, Marcel; Schott, Brigitte; Benardeau, Agnes; Tozzo, Effie; Kitas, Eric published 《Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase》.Bioorganic & Medicinal Chemistry Letters published the findings.Product Details of 3034-22-8 The information in the text is summarized as follows:
A novel sulfonylureido pyridine series exemplified by compound 19 (I) yielded potent inhibitors of FBPase showing significant glucose reduction and modest glycogen lowering in the acute db/db mouse model for Type-2 diabetes. Our inhibitors occupy the allosteric binding site and also extend into the dyad interface region of tetrameric FBPase. The experimental part of the paper was very detailed, including the reaction process of 5-Bromothiazol-2-amine(cas: 3034-22-8Product Details of 3034-22-8)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Product Details of 3034-22-8
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica