The author of 《4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching》 were Leoni, Alberto; Frosini, Maria; Locatelli, Alessandra; Micucci, Matteo; Carotenuto, Claudio; Durante, Miriam; Cosconati, Sandro; Budriesi, Roberta. And the article was published in European Journal of Medicinal Chemistry in 2019. Reference of 5-Bromothiazol-2-amine The author mentioned the following in the article:
Synthesis, characterization and evaluation of neuroprotective effects of a focused library of 4-imidazo[2,1-b]thiazole-1,4-dihydropyridines I [R = 2-FC6H4, 4-ClC6H4, 4-O2NC6H4, etc.; R1 = Me, Et, H2C=CHCH2; R2 = H, Me, Et, F, Cl, Br; R3 = H, Me]. Furthermore, the dihydropyridines were subjected to functional in vitro assays in cardiac tissues and vascular smooth muscle to determine their possible selectivity in counteracting the effects of neurodegeneration. In particular the strategy adopted for designing the compounds involved the imidazo[2,1-b]thiazole nucleus. The observed properties showed that substituents at C2 and C6 of the bicyclic scaffold were able to influence the cardiovascular parameters and the neuroprotective activity. In comparison to nifedipine, a set of derivatives such as compound I [R = CF3; R1 = Me; R2 = Me; R3 = H], showed a neuroprotective profile of particular interest. The experimental process involved the reaction of 5-Bromothiazol-2-amine(cas: 3034-22-8Reference of 5-Bromothiazol-2-amine)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Reference of 5-Bromothiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica