The author of 《Synthesis of Imidazo[1,2-a]pyridines and Imidazo[2,1-b]thiazoles Attached to a Cycloalkyl or Saturated Heterocycle Containing a Tertiary Hydroxy Substitution》 were Chenna Reddy, M. L.; Patil, Vineetkumar B.; Nawaz Khan, Fazlur Rahman; Saravanan, Vadivelu. And the article was published in Journal of Heterocyclic Chemistry in 2019. Application of 3034-22-8 The author mentioned the following in the article:
A new method has been developed for the synthesis of imidazo[1,2-a]pyridines I (R = H, Me, CN, Br, OMe, etc.; R1 = R2 = H; R1R2 = CH=CH-CH=CH; RR1 = CH=CH-CH=CH; X = CH2, O, S; n = 0, 1, 2), imidazo[2,1-b]thiazoles II (R3 = H, Me, Br, Cl, COOMe; X = CH2, O, S; n = 0, 1, 2), and benzo[d]imidazo[2,1-b]thiazoles III (R4 = H, OMe, Br, F, CF3) attached to a cycloalkyl or saturated heterocycle containing a tertiary hydroxy substitution. Readily available substituted 2-aminopyridines, 2-aminothiazoles, and 2-aminobenzothiazoles were treated with bromohydroxycycloalkyl ethanones IV to afford the desired products in good yields. In the experiment, the researchers used 5-Bromothiazol-2-amine(cas: 3034-22-8Application of 3034-22-8)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Application of 3034-22-8
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica