In 2003,Razus, Alexandru C.; Birzan, Liviu; Nae, Stefania; Surugiu, Mirela Nina; Cimpeanu, Valentin published 《Azulene-1-azo-2′-thiazoles. Synthesis and properties》.Journal of Heterocyclic Chemistry published the findings.Reference of 5-Bromothiazol-2-amine The information in the text is summarized as follows:
Several derivatives belonging to a new compound class, namely azulene-1-azo-2′-thiazoles, were prepared by the diazotization of 2-aminothiazoles in the presence of HNO3/H3PO4 followed by the coupling of diazonium salts with azulenes in buffered medium. The reactions proved to be general for this class, with the yields being considerably influenced by the thiazole substituents. For the first time a N-oxide of an amino-substituted five-membered nitrogen heterocycle was diazotized and coupled. The structure of the obtained azo dyes was assigned and their physico-chem. properties were discussed. The new azulene azo derivatives exhibit a strong bathochromic shift in their UV-visible spectra due to the intense push-pull effect of the azulene aromatic system and the intrinsic properties of the thiazole moiety. In the part of experimental materials, we found many familiar compounds, such as 5-Bromothiazol-2-amine(cas: 3034-22-8Reference of 5-Bromothiazol-2-amine)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Reference of 5-Bromothiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica