Shruthy, V. S.; Yusuf, Shakkeela published the artcile< In silico design, docking, synthesis and evaluation of thiazole Schiff bases>, Formula: C9H7N3O2S, the main research area is thiazole Schiff base preparation antiinflammatory anticancer protein kinase docking; cinnamaldehyde thiazole condensation.
A series of substituted Schiff base derivatives of 4-Ph thiazoles designed as anticancer and anti-inflammatory agents using computational methods was synthesized. The thiazole derivatives were selected based on docking studies performed on active site of protein tyrosine kinase (PDB :1T46) for anticancer activity and protein kinase (PDB :3DPK) for anti-inflammatory activity using Schrodinger 9.3 software. Mols. with better docking score was subjected to anal. for cytotoxic activity by in vitro MTT assay on cervical cancer HeLa cell lines and anti-inflammatory activity. Among the five thiazole derivatives, (4-(4-Methoxyphenyl)-N-3-phenylprop-2-en-1-ylidene-1,3-thiazol-2-amine) was found to have highest docking score and the same exhibited maximum in vitro cytotoxic and antiinflammatory activity. Thiazole schiff bases derivatives showed good antinflammatory and cytotoxic activity as predicted using mol. docking on resp. receptors.
International Journal of Pharmacy and Pharmaceutical Sciences published new progress about Anti-inflammatory agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Formula: C9H7N3O2S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica