Chen, Fei; Chai, Hui; Su, Ming-Bo; Zhang, Yang-Ming; Li, Jia; Xie, Xin; Nan, Fa-Jun published the artcile< Potent and Orally Efficacious Bisthiazole-Based Histone Deacetylase Inhibitors>, Quality Control of 31825-95-3, the main research area is bisthiazole histone deacetylase inhibitor preparation evaluation exptl autoimmune encephalomyelitis; Histone deacetylase inhibitors; bisthiazole; largazole.
Inspired by the thiazole-thiazoline cap group in natural product largazole, a series of structurally simplified bisthiazole-based histone deacetylase inhibitors was prepared and evaluated. Compound I was evaluated in vivo in an exptl. autoimmune encephalomyelitis (EAE) model and found to be orally efficacious in ameliorating clin. symptoms of EAE in mice.
ACS Medicinal Chemistry Letters published new progress about Experimental allergic encephalomyelitis (model for multiple sclerosis). 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Quality Control of 31825-95-3.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica