Wang, Anni; Li, Xuewei; Ju, Yong; Chen, Dongying; Lu, Jianzhong published the artcile< Bioluminescence imaging of carbon monoxide in living cells based on a selective deiodination reaction>, Application In Synthesis of 2591-17-5, the main research area is bioluminescence imaging carbon monoxide deiodination.
D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP. It was used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications. Herein, the iodination of D-luciferin was undertaken and explored as a bioluminescence probe without the need for light excitation to sensitively trace and image carbon monoxide (CO) in liver cancer cells. The bioluminescent probe (7′-iodo-luciferin) exhibited excellent selectivity for CO detection in vitro. This new probe could image exogenous and endogenous CO in the luciferase-transfected cancer cells. This new probe might be used for evaluating the roles of CO in various biol. processes.
Analyst (Cambridge, United Kingdom) published new progress about Bioluminescent imaging. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Application In Synthesis of 2591-17-5.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica