Sharma, G. M.; Parshad, Baldev; Narang, K. S. published the artcile< Thiazole derivatives. VI. Synthesis of 2-chloro-5-bromothiazoles>, Safety of 5-Bromo-2-chlorothiazole, the main research area is chloro bromo thiazoles; bromo chloro thiazoles; thiazoles chloro bromo.
The title compounds (I) were prepared as follows: ω – thiocyano ketones, NCSCH2C:OR were dissolved in CCl4 or C6H6, depending upon their solubilities, equivalent amounts C5H5N added, and an equivalent amount Br in the same solvent added dropwise at 40-50°. The solvent was distilled in vacuo, the residue treated with H2O to remove C5H5N.HBr, the ω-bromo-ω-thiocyano ketones RCOCH2SCN (II) were collected, washed, and crystallized from EtOH, solutions of II in dry ether saturated with dry HCl gas at 0°, the mixtures kept 12 hrs. at room temperature, the ether was decanted, and the residue purified either by distillation or crystallization to afford 2-chloro-5-bromothiazoles (III). The following II and III were prepared [R, m.p. II, % yield II, m.p. (or b.p./mm.) III, and % yield given]: Ph, 74°, 55.5, (155°/7), 67.6; p-MeC6H4, 94°, 54.5, 64°, 66.03; p-MeOC6H4, 81°, 86.2, 96°, 69.8; p-ClC6H4, 136°, 67.8, 85°, 70.9; p-BrC6H4, 120°, 71.6, 108°, 66.7.
Indian Journal of Chemistry published new progress about Cyclization. 3034-56-8 belongs to class thiazole, and the molecular formula is C3HBrClNS, Safety of 5-Bromo-2-chlorothiazole.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica