Schneider, Tanya L.; Walsh, Christopher T.; O’Connor, Sarah E. published the artcile< Utilization of Alternate Substrates by the First Three Modules of the Epothilone Synthetase Assembly Line>, Product Details of C12H18N2O4S, the main research area is substrate specificity epothilone synthetase Sorangium serine polyketide oxazole analog.
The epothilones, a family of macrolactone natural products produced by the myxobacterial species Sorangium cellulosum, are of current clin. interest as antitumor agents. Inspection of the structure of the epothilones suggests a hybrid polyketide/nonribosomal peptide biosynthetic origin, and the recent sequencing of the epothilone biosynthetic gene cluster has validated this proposal. Here we have examined unnatural substrates with the first two enzymes of the biosynthetic pathway, EpoA and EpoB, to investigate the enzymic construction of alternate heterocyclic structures and the subsequent elongation of these products by the third enzyme of the pathway, EpoC. The epothilone biosynthetic machinery can utilize serine to install an oxazole in place of a thiazole in the epothilone structure and will tolerate functionalized donor groups from the EpoA-ACP domain to produce epothilone fragments modified at the C21 position. These studies with the early enzymes of the epothilone biosynthesis cluster suggest that combinatorial biosynthesis may be a viable means for producing a variety of epothilone analogs that incorporate diversity into the heterocycle starter unit.
Journal of the American Chemical Society published new progress about Sorangium cellulosum. 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, Product Details of C12H18N2O4S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica