Raut, D. G.; Sonawane, K. D.; Jadhav, S. Y.; Sonawane, V. D.; Jadhav, D. B.; Dhanavade, M. J.; Bhosale, R. B. published the artcile< Synthesis and potential antibacterial activities of 2-chloro-N-(4-phenylthiazol-2-yl)acetamide derivatives>, Category: thiazole, the main research area is phenylthiazolyl chloroacetamide preparation antibacterial.
A series of substituted 2-chloro-N-(4-phenylthiazol-2-yl)acetamide derivatives I [R = H, 4-OMe, 3-NO2, 2,4-Cl2, etc.] were synthesized via condensation between 4-(substituted phenyl)-2-aminothiazoles with chloroacetyl chloride. The synthesized compounds were evaluated for antibacterial activity at three concentrations (25 μg/mL, 50 μg/mL and 100 μg/mL) and results were expressed in terms of zone of inhibition in millimeters by agar well diffusion method using Ampicillin 1mg/mL as reference standard drug. Among the tested compounds, compounds I [R = H, 4-OMe, 2,4-Cl2] showed the potent antibacterial activity against Gram pos. bacteria Bacillus subtilis and Gram neg. bacteria Salmonella typhimurium.
Pharma Chemica published new progress about Acetamides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Category: thiazole.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica