Bernier, Jean Luc; Houssin, Raymond; Henichart, Jean Pierre published the artcile< Analog of dolastatin 3. Synthesis, proton NMR studies, and spatial conformation>, COA of Formula: C12H18N2O4S, the main research area is dolastatin 3 analog preparation conformation.
Dolastatin 3 analog I was prepared by deblocking Boc-Pro-Leu-Val-(gly)Thz-(gly)Thz-ONSu (II; Boc = Me3CO2C, NSu = succinimido) by HBr/HOAc and cyclizing the resulting H-Pro-Leu-Val-(gly)Thz-(gly)Thz-ONSu.HBr in pyridine. Boc-Gly-NH2 underwent thionation via the Lawesson procedure to give Boc-Gly(S)-NH2, which was cyclized with CH3COCO2Et to give Boc-(gly)Thz-OEt (III). III was Boc-deblocked by HBr/HOAc to give H-(gly)Thz-OEt.HBr (IV), whereas III was saponified to give Boc-(gly)Thz-OH (V). V was coupled with IV by DCC/HOBt to give Boc-(gly)Thz-(gly)Thz-OEt, which was Boc-deblocked and then coupled with Boc-Pro-Leu-Val-OH by DCC/HOBt to give Boc-Pro-Leu-Val-(gly)Thz-(gly)Thz-OEt, which was converted into II. A spatial mol. conformation of I was proposed based on 1H NMR spectroscopy.
Tetrahedron published new progress about Cyclic peptides Role: SPN (Synthetic Preparation), PREP (Preparation). 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, COA of Formula: C12H18N2O4S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica