Takeda, Yasuyuki; Uoto, Kouichi; Iwahana, Michio; Jimbo, Takeshi; Nagata, Motoko; Atsumi, Ryo; Ono, Chiho; Tanaka, Noriko; Terasawa, Hirofumi; Soga, Tsunehiko published the artcile< New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 5>, Related Products of 1003-32-3, the main research area is taxoid preparation dihydrobaccatin acetal; taxane acetal preparation antitumor metabolic stability.
To improve the metabolic stability of I, which exhibited both in vitro antitumor activity and in vivo efficacy by both iv and po administration, we designed and synthesized new taxane analogs. Most of the synthetic compounds maintained excellent antitumor activity and were scarcely metabolized by human liver microsomes. And some compounds exhibited potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration similarly to I.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Related Products of 1003-32-3.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica