Computed Properties of C7H5ClN2SOn May 31, 2020, Acar Cevik, Ulviye; Osmaniye, Derya; Saglik, Beguem N.; Levent, Serkan; Cavusoglu, Betuel K.; Karaduman, Abdullah B.; Oekay, Uemide D.; Ozkay, Yusuf; Kaplancikli, Zafer A.; Turan, Guelhan published an article in Journal of Heterocyclic Chemistry. The article was 《Synthesis of new benzothiazole derivatives bearing thiadiazole as monoamine oxidase inhibitors》. The article mentions the following:
In this study, a novel series of benzothiazole-thiadiazole I (R1 = Et, methoxyethyl, n-Pr, n-Bu; R2 = H, Cl, NO2) was synthesized. These compounds I were evaluated as inhibitors for types A and B MAO enzymes. Compounds I [(A), R1 = methoxyethyl, R2 = NO2; R1 = n-Bu, R2 = NO2, (B)] were the most active derivatives in the series with IC50 values of 0.107 ± 0.003 and 0.128 ± 0.004, resp. Furthermore, compounds (A) and (B) were investigated for their cytotoxicity and found as non-cytotoxic. After reading the article, we found that the author used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Computed Properties of C7H5ClN2S)
6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Computed Properties of C7H5ClN2SThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica