Jiang, Xingyu; Beiger, Jason J.; Hartwig, John F. published the artcile< Stereodivergent Allylic Substitutions with Aryl Acetic Acid Esters by Synergistic Iridium and Lewis Base Catalysis>, HPLC of Formula: 1003-32-3, the main research area is stereodivergent allylic substitution iridium Lewis base; chiral allyl arylacetic ester preparation mol crystal structure; iridium Lewis base stereodivergent allylic substitution synergistic catalyst.
The preparation of all possible stereoisomers of a given chiral mol. bearing multiple stereocenters by a simple and unified method is a significant challenge in asym. catalysis. We report stereodivergent allylic substitutions with aryl acetic acid esters catalyzed synergistically by a metallacyclic iridium complex and benzotetramisole. Through permutations of the enantiomers of the two chiral catalysts, all four stereoisomers of the products bearing two adjacent stereocenters, e.g., I, are accessible with high diastereoselectivity and enantioselectivity. The resulting chiral activated ester products can be converted readily to enantioenriched amides, unactivated esters, and carboxylic acids in a one-pot manner.
Journal of the American Chemical Society published new progress about Allylic substitution reaction (stereoselective). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, HPLC of Formula: 1003-32-3.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica