Uppal, Archana; Kothiyal, Preeti; Singh, Anita published the artcile< Hybrid Class Phenylthiazole and 1,2,3,4-Tetrahydronaphthalene Target Sertraline Transporter for Antidepressant Action Revealed by Molecular Docking Studies>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is phenylthiazolyltetrahydronaphthalene derivative preparation antidepressant activity; epoxytetrahydronaphthalene preparation amine addition.
Phenylthiazolyl-substituted 1,2,3,4-tetrahydronaphthalene derivatives e. g., I, were synthesized, and their chem. structures were elucidated by Fourier transform IR, 1H-NMR, 13C-NMR spectral data and elemental analyses. Antidepressant-like activities of these compounds were screened using both Porsolt’s behavioral despair on albino mice and tail suspension tests. Open field test was also performed for the examination of probable neurol. deficits, which may interfere with the test results. The test compounds exhibited different levels of antidepressant activities. Addnl., the key ligand was further substantiated by docking experiment to explore plausible mode of binding in mol. dynamics overflow. The studies elucidates role of a hydrophilic H-bonding region and pi-cation binding as a major driving force for biol. activity.
Journal of Heterocyclic Chemistry published new progress about Addition reaction. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica