Fretaud, Maxence; Descamps, Delphyne; Laubreton, Daphne; Rameix-Welti, Marie-Anne; Eleouet, Jean-Francois; Larcher, Thibaut; Galloux, Marie; Langevin, Christelle published the artcile< New look at RSV infection: tissue clearing and 3D imaging of the entire mouse lung at cellular resolution>, Product Details of C11H8N2O3S2, the main research area is mouse lung RSV infection cellular resolution tissue clearing imaging; 3D imaging of lungs; RSV infection; RSV tropism; inclusion bodies; tissue clearing; viral pathophysiology.
Respiratory Syncytial Virus (RSV) is the major cause of severe acute respiratory tract illness in young children worldwide and a main pathogen for the elderly and immune-compromised people. In the absence of vaccines or effective treatments, a better characterization of the pathogenesis of RSV infection is required. To date, the pathophysiol. of the disease and its diagnosis has mostly relied on chest X-ray and genome detection in nasopharyngeal swabs. The development of new imaging approaches is instrumental to further the description of RSV spread, virus-host interactions and related acute respiratory disease, at the level of the entire lung. By combining tissue clearing, 3D microscopy and image processing, we developed a novel visualization tool of RSV infection in undissected mouse lungs. Whole tissue anal. allowed the identification of infected cell subtypes, based on both morphol. traits and position within the cellular network. Furthermore, 3D imaging was also valuable to detect the cytoplasmic viral factories, also called inclusion bodies, a hallmark of RSV infection. Whole lung clearing and 3D deep imaging represents an unprecedented visualization method of infected lungs to allow insight into RSV pathophysiol. and improve the 2D histol. analyses.
Viruses published new progress about Acute respiratory disease. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Product Details of C11H8N2O3S2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica