Komiyama, Masato; Tsuchiya, Hideyoshi; Teramoto, Mitsuru; Yajima, Naoki; Kurokawa, Masayuki; Minamizono, Kunio; Tsuchiya, Naoki; Kato, Yoshiaki; Sato, Yoshinori; Dohi, Masahiko published the artcile< Process Development of Febuxostat Using Palladium- and Copper-Catalyzed C-H Arylation>, Electric Literature of 20582-55-2, the main research area is Febuxostat process synthesis palladium copper catalyzed arylation thiazole bromoarene.
There is significant interest in the development of process routes for active pharmaceutical ingredients using C-H arylation methodol. An efficient and practical synthetic route for febuxostat, which is the first non-purine-type xanthine oxidase inhibitor, was established via palladium- and copper-catalyzed C-H arylation of thiazole with aryl bromide. The catalyst loading was reduced to 0.1 mol % for the intermol. C-H arylation, and a three-step synthesis produced febuxostat in 89% overall yield with excellent selectivity.
Organic Process Research & Development published new progress about Arylation. 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Electric Literature of 20582-55-2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica