The author of 《Silica-Supported P2O5 as an Efficient Heterogeneous Catalyst for the One Pot Synthesis of 3-Amino-imidazo[2,1-b](1,3)benzothiazole under Green Conditions》 were Khan, Takallum; Yadav, Ritu. And the article was published in Journal of Heterocyclic Chemistry in 2019. Quality Control of 6-Chlorobenzothiazol-2-ylamine The author mentioned the following in the article:
The new approach involving the solid supported catalyst for the formation of C-N bond followed by cyclization has been reported. In this work we have reported a facile, efficient, and environment-friendly protocol for the synthesis of some new 3-amino-imidazo[2,1-b](1,3)benzothiazole derivatives by one-pot condensation of 2-aminobenzothiazole, indole-3-carbaldehyde, and aryl isocyanide in the presence of silica-supported P2O5 as a heterogeneous solid acid catalyst. The reaction was performed using conventional method under green conditions. The present approach offers the advantages of simple methodol., inexpensive acid catalyst, short reaction time, easy work up with excellent yield, simple purification and use of green solvent. All the newly synthesized compounds were characterized in details using phys. and chem. techniques such as m.p., 1H NMR, 13C NMR, and FTIR spectroscopy. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Quality Control of 6-Chlorobenzothiazol-2-ylamine)
6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Quality Control of 6-Chlorobenzothiazol-2-ylamineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica