COA of Formula: C7H5ClN2SOn March 31, 2020, Zhang, Zhen; Gu, Ying-Lin; Wang, Zheng-Yang; Wang, Huan-Nan; Zhao, Yan; Chu, Xue-Mei; Zhang, Chun-Yan; Yan, Mao-Cai published an article in Journal of Heterocyclic Chemistry. The article was 《Synthesis and biological evaluation of novel indoleamide derivatives as antioxidative and antitumor agents》. The article mentions the following:
Novel indole amide derivatives I [R = pyrazin-2-amino, (2-methoxy-1-methyl-2-oxo-ethyl)amino, (2-oxoazepan-3-yl)amino, etc.] were successfully synthesized and characterized by 1H NMR, 13C NMR, IR, MS, and elemental anal., and their mol. formulas were C14H10N6O, C13H10N4O, C16H13N3O2, C19H14N2O2, C16H11N3OS, C15H13N3O, C12H9N5O, C16H10ClN3OS, C15H17N3O2 and C13H14N2O3, resp. The primary biol. activities of these compounds I were evaluated in-vitro by the DPPH assay, H2O2 induced oxidative stress injury assay and cytotoxicity assay. The results indicated that compounds I [R = imidazo[4,5-d]pyridazin-4-amino, pyrazin-2-amino, 7-hydroxynaphthalen-1-amino, 5H-1,2,4-triazin-4-amino, (2-oxoazepan-3-yl)amino] exhibited DPPH·scavenging ability, while I [R = 2-carbamoylanilino, 7-hydroxynaphthalen-1-amino, 1,3-benzothiazol-2-amino, 6-chloro-1,3-benzothiazol-2-amino] showed potent growth-inhibitory activities against various human tumor cells, including MDA-MB-231, Hela, A549 and HT29. Interestingly, compound I [R = 7-hydroxynaphthalen-1-amino] showed potent scavenging effects on the DPPH radical and possessed protective effect on H2O2-induced oxidative stress injury in human neuroblastoma SH-SY5Y cells at low concentrations; however, I [R = 7-hydroxynaphthalen-1-amino] exhibited significant toxicity against four human tumor cells at a higher concentration in all treatments, and the range of IC50 value was 7.91 to 13.35μM. The experimental part of the paper was very detailed, including the reaction process of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9COA of Formula: C7H5ClN2S)
6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.COA of Formula: C7H5ClN2SThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica