《Synthesis, characteristic fragmentation patterns and antibacterial activity of new azo compounds from the coupling reaction of diazobenzothiazole ions and acetaminophen》 was published in Heterocyclic Communications in 2021. These research results belong to Tsemeugne, Joseph; Nangmo, Pamela Kemda; Mkounga, Pierre; De Dieu Tamokou, Jean; Kengne, Irene Chinda; Edwards, Giles; Sopbue, Emmanuel Fondjo; Nkengfack, Augustin Ephrem. HPLC of Formula: 95-24-9 The article mentions the following:
A series of azobenzothiazole dyes were synthesized via diazotization of substituted benzothiazole derivatives followed by azo coupling with acetaminophen. The chem. structures of all synthesized compounds were confirmed using anal. data and spectroscopic techniques, including UV-visible, IR, mass spectra and 1H- and 13C-NMR. The in situ formed diazobenzothiazole ions regiospecifically reacted with acetaminophen derivatives in the Hollemann-guided electrophilic aromatic substitution mechanism. The regio-orientations were established, on the one hand, by a rigorous interpretation of 1H-NMR spectra and, on the other hand, by the characteristic fragmentation patterns observed on the electrospray mass spectra. In the cases of I and II, multisubstitutions occurred. The antimicrobial activity of synthesized azobenzothiazole dyes, along with all the starting materials, was investigated on Pseudomonas aeruginosa PA01, Staphylococcus aureus 18, Escherichia coli 64R and S. aureus ATCC 25923. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was 1,2-bis(benzo[d]thiazol-2-yl)diazene trihydrate. In the experiment, the researchers used many compounds, for example, 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9HPLC of Formula: 95-24-9)
6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.HPLC of Formula: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica