Inouye, Satoshi; Nakamura, Mitsuhiro; Taguchi, Jumpei; Hosoya, Takamitsu published the artcile< Identification of a novel oxidation product from yellow fluorophore in the complex of apoPholasin and dehydrocoelenterazine>, Application of C11H8N2O3S2, the main research area is oxidation yellow fluorophore complex apoPholasin dehydrocoelenterazine; Coelenteramide; Coelenteramine; Coelenterazine; Photoproteins; Reactive oxygen.
The complex of the recombinant fusion protein of apoPholasin and glutathione S-transferase (GST-apoPholasin) with non-fluorescent dehydrocoelenterazine (dCTZ) (GST-apoPholasin/dCTZ complex) shows yellow fluorescence at 539 nm by excitation at 430 nm. The GST-apoPholasin/dCTZ complex with a fluorophore (dCTZ*) has considerably weak luminescence activity, converting slowly to a blue fluorescence protein with the emission peak at 430 nm. The main oxidation products from dCTZ* for blue fluorescence were identified as coelenteramine (CTM) and an unreported pyrazine derivative, 3-benzyl-5-(4-hydroxyphenyl)pyrazin-2(1H)-one (CTO) that was confirmed by chem. synthesis.
Bioorganic & Medicinal Chemistry Letters published new progress about Chimeric fusion proteins Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (GST-apoPholasin). 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Application of C11H8N2O3S2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica