Wu, Xiongyu; Oehrngren, Per; Ekegren, Jenny K.; Unge, Johan; Unge, Torsten; Wallberg, Hans; Samuelsson, Bertil; Hallberg, Anders; Larhed, Mats published the artcile< Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary-Alcohol-Containing Transition-State Mimic>, Synthetic Route of 198904-53-9, the main research area is tertiary alc derivative preparation crystal structure HIV1 protease inhibitor.
A new generation of HIV-1 protease inhibitors encompassing a tertiary-alc.-based transition-state mimic has been developed. By elongation of the core structure of recently reported inhibitors with two carbon atoms and by varying the P1′ group of the compounds, efficient inhibitors were obtained with Ki down to 2.3 nM and EC50 down to 0.17 μM. Two inhibitor-enzyme x-ray structures are reported.
Journal of Medicinal Chemistry published new progress about AIDS (disease). 198904-53-9 belongs to class thiazole, and the molecular formula is C10H7NOS, Synthetic Route of 198904-53-9.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica