Horiuchi, Takao; Takeda, Yasuyuki; Haginoya, Noriyasu; Miyazaki, Masaki; Nagata, Motoko; Kitagawa, Mayumi; Akahane, Kouichi; Uoto, Kouichi published the artcile< Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based cyclin-dependent kinase 4 inhibitors: synthesis, biological evaluation and structure-activity relationships>, Recommanded Product: Thiazole-5-carboxyaldehyde, the main research area is thienopyrimidinyl hydrazone preparation biol activity cyclin dependent kinase inhibitor; anticancer agent thienopyrimidinyl hydrazone preparation structure activity relationship; structure activity relationship thienopyrimidinyl hydrazone preparation CDK4 inhibitor.
The design, synthesis, and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazones, e.g. I, as cyclin-dependent kinase 4 (CDK4) inhibitors are described. In continuing our program aim to search for potent CDK4 inhibitors, the introduction of a thiazole group at the hydrazone part has led to marked enhancement of chem. stability. Furthermore, by focusing on the optimization at the C-4′ position of the thiazole ring and the C-6 position of the thieno[2,3-d]pyrimidine moiety, compound I has been identified with efficacy in a xenograft model of HCT116 cells. In this paper, the potency, selectivity profile, and structure-activity relationships of our synthetic compounds are discussed.
Chemical & Pharmaceutical Bulletin published new progress about Antitumor agents. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Recommanded Product: Thiazole-5-carboxyaldehyde.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica