53266-94-7, An article , which mentions 53266-94-7, molecular formula is C7H10N2O2S. The compound – Ethyl 2-(2-aminothiazol-4-yl)acetate played an important role in people’s production and life.
The synthesis of different diazonium salts derived from homo- and heterocyclic aromatic amines bearing anionic residues is described.The chemical stabilities of these compounds were established at different pH’s, and the compounds were tested accordingly in binding experiments for the rat brain gamma-aminobutyric acid (GABA) receptor, for which they could ultimately be used as irreversible affinity or photoaffinity probes.The aromatic heterocyclic series studied were 2-aminoimidazole, 2-aminothiazole, and 4-aminopyridine N-oxide.The derived diazonium salts are unstable compounds at neutral pH unless they are able to be deprotonated to the corresponding diazo form.As such, the 2-diazoimidazole-4(5)-acetic acid (3b) is stable in neutral medium and recognizes the GABA receptor (IC50 = 70 muM).The homocyclic aromatic diazonium salt showed sufficient stability to be tested in binding experiments.The diazonium salts derived from m-sulfanic acid and 8-sulfonaphthylamine were the most interesting (10b, IC50 = 10 muM; 15b, IC50 < 100 muM).In this series, the compounds that deprotonate at neutral pH (hydroxybenzenediazonium derivatives 12b-14b) showed increased chemical stability but decreased affinity for the GABA receptor.This difference between the diazoimidazole and the diazohydroxybenzene series is attributed to a different charge distribution between the two series.The ligands 3b,10b, and 15b can be used as potential irreversible probes for the GABA receptor. The synthesis of different diazonium salts derived from homo- and heterocyclic aromatic amines bearing anionic residues is described.The chemical stabilities of these compounds were established at different pH's, and the compounds were tested accordingly in binding experiments for the rat brain gamma-aminobutyric acid (GABA) receptor, for which they could ultimately be used as irreversible affinity or photoaffinity probes.The aromatic heterocyclic series studied were 2-aminoimidazole, 2-aminothiazole, and 4-aminopyridine N-oxide.The derived diazonium salts are unstable compounds at neutral pH unless they are able to be deprotonated to the corresponding diazo form.As such, the 2-diazoimidazole-4(5)-acetic acid (3b) is stable in neutral medium and recognizes the GABA receptor (IC50 = 70 muM).The homocyclic aromatic diazonium salt showed sufficient stability to be tested in binding experiments.The diazonium salts derived from m-sulfanic acid and 8-sulfonaphthylamine were the most interesting (10b, IC50 = 10 muM; 15b, IC50 < 100 muM).In this series, the compounds that deprotonate at neutral pH (hydroxybenzenediazonium derivatives 12b-14b) showed increased chemical stability but decreased affinity for the GABA receptor.This difference between the diazoimidazole and the diazohydroxybenzene series is attributed to a different charge distribution between the two series.The ligands 3b,10b, and 15b can be used as potential irreversible probes for the GABA receptor. If you are interested in 53266-94-7, you can contact me at any time and look forward to more communication.53266-94-7
Reference£º
Thiazole | C3H10697NS – PubChem,
Thiazole | chemical compound | Britannica