Fereidoonnezhad, Masood; Ahmadi Mirsadeghi, Hasti; Abedanzadeh, Sedigheh; Yazdani, Alireza; Alamdarlou, Arsalan; Babaghasabha, Mojgan; Almansaf, Zainab; Faghih, Zeinab; McConnell, Zachary; Shahsavari, Hamid R.; Beyzavi, M. Hassan published the artcile< Synthesis and biological evaluation of thiolate gold(I) complexes as thioredoxin reductase (TrxR) and glutathione reductase (GR) inhibitors>, COA of Formula: C3H5NS2, the main research area is gold thiolate complex preparation antitumor thioredoxin glutathione reductase; crystal structure gold thiolate complex.
New gold(I) thiolate complexes [(PPh2py)Au(SR)] (PPh2py = 2-(diphenylphosphino)pyridine and SR = the deprotonated form of pyridine-2-thiol (HSpy, 1a), pyrimidine-2 thiol (HSpyN, 1b), benzothiazole-2-thiol (HSbt, 1c) and 2-thiazoline-2-thiol (HSt, 1d)) were prepared by the reaction of chloro gold complex [(PPh2py)AuCl], A, with the corresponding in situ generated thiolate salt (through a nucleophilic substitution reaction) under inert conditions. All complexes were characterized by NMR spectroscopy and the structures of 1b and 1d were further identified by single crystal x-ray determination An in vitro cytotoxicity evaluation against five human cancer cell lines including A549 (nonsmall cell lung cancer), SKOV3 (human ovarian cancer), MCF-7 (human breast cancer), SW1116 (colon cancer) and HeLa (cervical cancer) demonstrated the promising antitumor effects of 1b in comparison with standard auranofin and cisplatin. The effects of these compounds on the proliferation of nontumoral breast cell line MCF-12A showed good selectivity among tumorigenic and nontumorigenic cell lines. 1B effectively produces cell death by inducing apoptosis in the MCF-7 human breast cancer cell line. These complexes inhibit both cytosolic (TrxR1) and mitochondrial (TrxR2) thioredoxin reductases as well as glutathione reductase (GR).
New Journal of Chemistry published new progress about Colon neoplasm. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, COA of Formula: C3H5NS2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica