39136-60-2, 5-Ethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2-(6-Methyl-1 H-indol-3-yl)acetic acid (100 mg, 0.53 mmol) was dissolved in DMF (7mL). 5-Ethylthiazol-2-amine (74.5 mg, 0.58 mmol) and DIPEA (0.18 mL, 0.7mmol) were added. PyBOP (302.5 mg, 0.58 mmol) was added and the reaction was stirred for 16 h at room temperature. The solvent was removed in vacuo. The residue was dis20 solved in EtOAc and washed twice with sat. aq. sodium bicarbonate solution, once withwater and once with sat. aq. sodium chloride solution. The organic phase was evaporated and the residue was purified by flash chromatography (gradient: 20-100% ethyl acetate in n-heptane). The solvent was evaporated and the title compound was obtained as an orange solid (107 mg, 0.36 mmol, 68% yield). UPLO-MS (Positive mode)m/z 300 (M+H). Retention time 1 .525 mm.
39136-60-2 5-Ethylthiazol-2-amine 12737257, athiazole compound, is more and more widely used in various.
Reference£º
Patent; EUROPEAN MOLECULAR BIOLOGY LABORATORY; WILL, David William; REID, George; CHARAPITSA, Iryna; LEWIS, Joe; (118 pag.)WO2018/229195; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica