Kitada, Nobuo; Saito, Ryohei; Obata, Rika; Iwano, Satoshi; Karube, Kazuma; Miyawaki, Atsushi; Hirano, Takashi; Maki, Shojiro A. published the artcile< Development of near-infrared firefly luciferin analogue reacted with wild-type and mutant luciferases>, COA of Formula: C11H8N2O3S2, the main research area is firefly luciferin luciferase near IR spectroscopy chemiluminescence; Akaluc; Photinus pyralis luciferase; TokeOni; luciferin analogues; luciferin-luciferase reaction; mutant luciferase; near-infrared bioluminescence.
Interestingly, only the D-form of firefly luciferin produces light by luciferin-luciferase (L-L) reaction. Certain firefly luciferin analogs with modified structures maintain bioluminescence (BL) activity; however, all L-form luciferin analogs show no BL activity. To this date, our group has developed luciferin analogs with moderate BL activity that produce light of various wavelengths. For in vivo bioluminescence imaging, one of the important factors for detection sensitivity is tissue permeability of the number of photons emitted by L-L reaction, and the wavelengths of light in the near-IR (NIR) range (700-900 nm) are most appropriate for the purpose. Some NIR luciferin analogs by us had performance for in vivo experiments to make it possible to detect photons from deep target tissues in mice with high sensitivity, whereas only a few of them can produce NIR light by the L-L reactions with wild-type luciferase and/or mutant luciferase. Based on the structure-activity relationships, we designed and synthesized here a luciferin analog with the 5-allyl-6-dimethylamino-2-naphthylethenyl moiety. This analog exhibited NIR BL emissions with wild-type luciferase (max = 705 nm) and mutant luciferase AlaLuc (max = 655 nm).
Chirality published new progress about Bioluminescence. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, COA of Formula: C11H8N2O3S2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica