Houssin, Raymond; Lohez, Michele; Bernier, Jean Luc; Henichart, Jean Pierre published the artcile< A convenient method for the preparation of 2-(1-aminoalkyl)thiazole-4-carboxylic acids, key intermediates in the total synthesis of naturally occurring antitumor cyclopeptides>, Safety of Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate, the main research area is thiazolecarboxylic acid aminoalkyl; thiazolyl amino acid; thioamide amino cyclocondensation bromopyruvate.
A convenient synthesis of 2-(1-aminoalkyl)thiazole-4-carboxylic acids I (Boc = Me3CO2C; R = H, Me, Me2CH, Me2CHCH2, EtCHMe, PhCH2) involving a Hantzsch condensation of BocNHCHRC(S)NH2 (II) with Et bromopyruvate is reported. The intermediate thioamides II are obtained from the corresponding amides by action of a Lawesson’s type reagent. This procedure constitutes a new access to key intermediates useful in the total synthesis of antitumor cyclopeptides extracted from marine animals.
Journal of Organic Chemistry published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, Safety of Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica