Lakhan, Ram; Singh, Om Prakash published the artcile< Local Anesthetics. Part III. Local anesthetic activity and synthesis of 2-(N-substituted or N,N-disubstituted aminoacetamido)-4-aryl thiazoles>, Reference of 57493-24-0, the main research area is anesthetic aminoacetamidoaryl thiazole.
Some new 2-(aminoacetamido)-4-phenylthiazoles [I; R’ = H or Et, R2 = H or alkyl, R1R2 = -(CH2)-5, X = NO2 or MeO, n = 1 or 2] were synthesized. Their hydrochlorides were screened for local anesthetic activity in the frog sciatic plexus preparation and this activity was compared with that of procaine hydrochloride. The 2-(N-substituted aminoacetamido)-4-m-nitrophenylthiazole hydrochlorides were the most potent, being almost twice as potent as procaine HCl in terms of the onset of anesthesia.
Agricultural and Biological Chemistry published new progress about Local anesthetics. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Reference of 57493-24-0.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica