Nicolaou, K. C.; Leung, Gulice Y. C.; Dethe, Dattatraya H.; Guduru, Ramakrishna; Sun, Ya-Ping; Lim, Chek Shik; Chen, David Y.-K. published the artcile< Chemical Synthesis and Biological Evaluation of Palmerolide A Analogues>, Product Details of C5H6N2OS, the main research area is palmerolide A analog preparation antitumor.
Mol. design and chem. synthesis of several palmerolide A analogs allowed the first structure activity relationships (SARs) of this newly discovered marine antitumor agent. From several analogs synthesized and tested, compounds I (with a Ph substituent on the side chain) and II (lacking the C-7 hydroxyl group) were the most interesting, exhibiting approx. a 10-fold increase in potency and equipotency, resp., to the natural product. These findings point the way to more focused structure activity relationship studies.
Journal of the American Chemical Society published new progress about Antitumor agents. 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Product Details of C5H6N2OS.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica