In 2018,Jo, Minmi; Won, Sun-Woo; Lee, Dong Guk; Jung, Jae-Kyung; Kim, Sunhong; Kwak, Young-Shin published 《An efficient synthetic protocol for amide derivatives of Boc-2-aminoisobutyrate》.Archives of Pharmacal Research published the findings.Recommanded Product: 5-Bromothiazol-2-amine The information in the text is summarized as follows:
Aminoisobutyric acid (AIB) is an important building block widely incorporated by medicinal chemists in mol. design. Owing to the steric challenge, elaborating AIB’s carboxylic acid using conventional amidation protocols is often problematic. We discovered that an amidation protocol utilizing Me Boc-aminoisobutyrate (Boc = tert-butoxycarbonyl) and magnesium amidates of various reactivities produces the corresponding amide derivatives in good to excellent yields. In the experimental materials used by the author, we found 5-Bromothiazol-2-amine(cas: 3034-22-8Recommanded Product: 5-Bromothiazol-2-amine)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: 5-Bromothiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica