Wang, Lu; Wang, Huaiyu; Meng, Weidong; Xu, Xiu-Hua; Huang, Yangen published an article on January 31 ,2021. The article was titled 《Facile syntheses of 3-trifluoromethylthio substituted thioflavones and benzothiophenes via the radical cyclization》, and you may find the article in Chinese Chemical Letters.Recommanded Product: 6-Chlorobenzothiazol-2-ylamine The information in the text is summarized as follows:
The 3-CF3S substituted thioflavones I (R1 = C6H5, 4-ClC6H4, 2-thienyl, etc.; R2 = Br) and benzothiophenes II (R3 = C6H5, 4-FC6H4, 2-thienyl, etc.; R4 = 6-Me, 6-Cl, 4,6-(Cl)2, etc.) were achieved via the reactions of AgSCF3 with methylthiolated alkynones 2-(SMe)-5-BrC6H3C(O)CCR1 and alkynylthioanisoles, R5CCR3 (R5 = 4-chloro-2-(methylsulfanyl)phenyl, 5-methyl-2-(methylsulfanyl)phenyl, 2,4-difluoro-6-(methylsulfanyl)phenyl, etc.) resp., promoted by persulfate. This protocol possesses good functional group tolerance and high yields. Mechanistic studies suggested that a classic two-step radical process involves addition of CF3S radical to triple bond and cyclization with SMe moiety. After reading the article, we found that the author used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Recommanded Product: 6-Chlorobenzothiazol-2-ylamine)
6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Recommanded Product: 6-Chlorobenzothiazol-2-ylamineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica