《TTL proteins scaffold brassinosteroid signaling components at the plasma membrane to optimize signal transduction in Arabidopsis》 was written by Amorim-Silva, Vitor; Garcia-Moreno, Alvaro; Castillo, Araceli G.; Lakhssassi, Naoufal; Esteban del Valle, Alicia; Perez-Sancho, Jessica; Li, Yansha; Pose, David; Perez-Rodriguez, Josefa; Lin, Jinxing; Valpuesta, Victoriano; Borsani, Omar; Zipfel, Cyril; Macho, Alberto P.; Botella, Miguel A.. Formula: C18H24N6O6S4 And the article was included in Plant Cell on August 31 ,2019. The article conveys some information:
Brassinosteroids (BRs) form a group of steroidal hormones essential for plant growth, development, and stress responses. BRs are perceived extracellularly by plasma membrane receptor-like kinases that activate an interconnected signal transduction cascade, leading to the transcriptional regulation of BR-responsive genes. TETRATRICOPEPTIDE THIOREDOXIN-LIKE (TTL) genes are specific for land plants, and their encoded proteins are defined by the presence of protein-protein interaction motives, i.e., an intrinsic disordered region at the N terminus, six tetratricopeptide repeat domains, and a C terminus with homol. to thioredoxins. TTL proteins thus likely mediate the assembly of multiprotein complexes. Phenotypic, mol., and genetic analyses show that TTL proteins are pos. regulators of BR signaling in Arabidopsis (Arabidopsis thaliana). TTL3 directly interacts with a constitutively active BRASSINOSTEROID INSENSITIVE1 (BRI1) receptor kinase, BRI1-SUPPRESSOR1 phosphatase, and the BRASSINAZOLE RESISTANT1 transcription factor and associates with BR-SIGNALING KINASE1, BRASSINOSTEROID INSENSITIVE2 kinases, but not with BRI1-Associated KINASE1. A functional TTL3-green fluorescent protein (GFP) shows dual cytoplasmic plasma membrane localization. Depleting the endogenous BR content reduces plasma membrane localization of TTL3-GFP, while increasing BR content causes its plasma membrane relocalization, where it strengthens the association of BR signaling components. Our results reveal that TTL proteins promote BR responses and suggest that TTL proteins may function as scaffold proteins by bringing together cytoplasmic and plasma membrane BR signaling components.ABTS Diammonium(cas: 30931-67-0Formula: C18H24N6O6S4) was used in this study.
ABTS Diammonium(cas: 30931-67-0) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Formula: C18H24N6O6S4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica