Li, Guoliang; He, Yundong; Zhou, Wenbo; Wang, Peng; Zhang, Yong; Tong, Weiguang; Wu, Haigang; Liu, Mingyao; Ye, Xiyun; Chen, Yihua published an article on February 1 ,2014. The article was titled 《Identification, synthesis and photo-protection evaluation of arylthiazole derivatives as a novel series of sunscreens》, and you may find the article in Heterocycles.Recommanded Product: 144060-98-0 The information in the text is summarized as follows:
A series of arylthiazole derivatives I [R3 = C6H5, C6H5CH2, C6H5CH2CH2], II [R1 = C6H5, 4-BrC6H4, 3-H3COC6H4, 2-H3COC6H4], III [n= 1, 2, 3, 5; R = H, n-Pr, n-Bu, Et; R2 = OMe, OEt] and IV [R1 = H, CF3, OMe, Cl; R2 = H, Cl; R3 = H, Cl] was designed and synthesized. Addnl., phenylfuran derivative V [X = O; Y = C; R = H], phenylthiophene derivative V [X = S; Y = C; R = H], phenyloxazole derivative V [X = O; Y = N; R = Me], N-(Ethoxycarbonylmethyl)-2-phenyl-4-thiazolecarboxamide and N-(Ethoxycarbonylmethyl)-3-phenyl-5-methyl-4-isooxazolecarboxamide were also prepared All the synthesized compounds were evaluated for their photo-protective effect against UVB exposure induced cellular damage in keratinocytes cell (HaCaT) and their structure-activity relationship (SAR) was discussed. Among the tested compounds, compound III [n = 1; R = Et; R2 = OEt] significantly protected the dorsal skin of BALB/c-nu mice against UVB-induced decrustation in vivo. The in vitro and in vivo data for these arylthiazole derivatives suggest further studies for their potential use as photo-protection agents as well as sunscreen candidates. After reading the article, we found that the author used 4-Methyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(cas: 144060-98-0Recommanded Product: 144060-98-0)
4-Methyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(cas: 144060-98-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 144060-98-0
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica